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ACCL TRINITY P1 3UM 3X150

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ACCL TRINITY P1 3UM 3X150

The Thermo Scientific™ Acclaim™ Trinity P1 HPLC Column (3 µm, 3.0 × 150 mm) is a premium mixed-mode analytical column designed for the simultaneous separation of active pharmaceutical ingredients (APIs), counter ions, and complex ionic mixtures in pharmaceutical, chemical, environmental, and research laboratories. Utilizing Nanopolymer Silica Hybrid (NSH) technology, the column combines reversed-phase (RP), strong cation-exchange (SCX), and weak anion-exchange (WAX) functionalities within a single stationary phase, delivering exceptional selectivity and chromatographic performance.

The unique trimodal surface chemistry allows independent optimization of reversed-phase and ion-exchange interactions by adjusting mobile phase pH, buffer concentration, and organic solvent composition. This flexibility simplifies method development while achieving superior resolution for ionic, ionizable, and neutral compounds without the need for ion-pairing reagents.

SKU: 75563 Category: Brand:

Specifications

Parameter Specification
Product Type Mixed-Mode HPLC Analytical Column
Brand Thermo Scientific™
Product Line Acclaim™ Trinity P1
Column Dimensions 3.0 × 150 mm
Particle Size 3 µm
Stationary Phase Reversed Phase + Strong Cation Exchange + Weak Anion Exchange
Technology Nanopolymer Silica Hybrid (NSH)
Particle Shape Spherical
Average Pore Size 120 Å
Surface Area 300 m²/g
Recommended pH Range 2.5–7.0
Maximum Operating Pressure 4500 psi (310 bar)
Recommended Flow Rate 0.30–1.60 mL/min (3.0 mm ID)
Maximum Temperature 60°C
Compatible Detectors UV, CAD, ELSD, MS
Primary Applications Pharmaceutical Analysis, Counter-Ion Analysis, Mixed-Mode HPLC

Features

  • Mixed-mode HPLC analytical column
  • Column dimensions: 3.0 × 150 mm
  • Particle size: 3 µm
  • Trimodal stationary phase chemistry
  • Combined Reversed Phase (RP), Strong Cation Exchange (SCX), and Weak Anion Exchange (WAX) functionality
  • Advanced Nanopolymer Silica Hybrid (NSH) technology
  • High-purity spherical silica particles
  • Excellent selectivity for pharmaceutical compounds
  • Simultaneous separation of APIs and counter ions
  • Effective retention of ionic and ionizable analytes
  • Flexible method development through independent control of retention mechanisms
  • Compatible with UV, ELSD, CAD, and MS detectors
  • Low column bleed for sensitive analytical applications
  • High chromatographic efficiency and reproducibility
  • Suitable for pharmaceutical, research, and analytical laboratories

Benefits

  • Three Separation Mechanisms in One Column: Combines reversed-phase, cation-exchange, and anion-exchange interactions to simplify complex separations.
  • Ideal for Pharmaceutical Analysis: Specifically developed for simultaneous separation of APIs and pharmaceutical counter ions with excellent resolution.
  • Simplified Method Development: Independent adjustment of pH, buffer concentration, and solvent composition allows rapid optimization of chromatographic conditions.
  • Excellent Peak Performance: Produces sharp peaks, high resolution, and reproducible analytical results.
  • MS-Compatible Operation: Low column bleed makes the column suitable for LC-MS, CAD, ELSD, and UV detection.
  • High Efficiency: The 3 µm particle technology provides improved separation efficiency while maintaining reliable pressure performance.
  • Versatile Mixed-Mode Selectivity: Capable of separating neutral, acidic, and basic compounds within a single chromatographic run.
  • Reliable Laboratory Performance: Manufactured and performance-tested to ensure consistent analytical results across pharmaceutical and research applications.

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