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HYPURITY ADVANCE 5UM 50X4.6MM COLUMN

The Thermo Scientific™ HyPURITY™ ADVANCE HPLC Column (5 µm, 50 × 4.6 mm) is a high-performance reversed-phase C8 analytical column designed for fast, reliable, and reproducible chromatographic separations. Built on HyPURITY™ 190 Å ultra-pure silica with a polar-embedded stationary phase, this column offers superior peak shape and alternate selectivity for compounds that exhibit poor chromatography on conventional C18 columns.

The HyPURITY™ ADVANCE column is particularly suitable for pharmaceutical analysis, bioanalytical testing, environmental monitoring, food safety, chemical analysis, and LC/MS applications. Its polar-embedded chemistry minimizes unwanted interactions with residual silanol groups, providing exceptional peak symmetry for acidic, basic, and chelating compounds while maintaining enhanced stability in highly aqueous mobile phases.

SKU: 21005-054630 Category: Brand:

Specifications

Parameter Specification
Product Type Analytical HPLC Column
Brand Thermo Scientific™
Product Series HyPURITY™ ADVANCE™
Chromatography Type Reversed Phase (RP-HPLC)
Stationary Phase Polar-Embedded C8
USP Classification L7
Column Dimensions 50 × 4.6 mm
Particle Size 5 µm
Pore Size 180 Å
Surface Area 200 m²/g
Carbon Load 9%
Packing Material High-Purity Silica
LC/MS Compatible Yes
Application Pharmaceutical, Environmental, Food & Chemical Analysis

Features

  • Analytical reversed-phase HPLC column
  • HyPURITY™ ADVANCE™ polar-embedded C8 stationary phase
  • Column dimensions: 50 × 4.6 mm
  • Particle size: 5 µm
  • High-purity 190 Å silica packing
  • Polar-embedded chemistry for alternate selectivity
  • Excellent peak shape for acidic, basic, and chelating compounds
  • Enhanced stability with highly aqueous mobile phases
  • Low column bleed suitable for LC/MS applications
  • Optimized for high-throughput fast analysis
  • Excellent batch-to-batch reproducibility
  • Designed for pharmaceutical and analytical laboratories
  • Compatible with conventional HPLC systems
  • Long column lifetime and reliable chromatographic performance

Benefits

  • Superior Peak Shape: Polar-embedded C8 chemistry minimizes secondary interactions, producing symmetrical peaks even for challenging analytes.
  • Fast Chromatographic Analysis: The 50 mm column length reduces run times while maintaining analytical performance.
  • Excellent LC/MS Compatibility: Low column bleed improves detector sensitivity and minimizes background noise.
  • Enhanced Aqueous Stability: Maintains consistent performance when using highly aqueous mobile phases.
  • Improved Selectivity: Offers an excellent alternative to traditional C18 columns for compounds requiring different retention characteristics.
  • Reliable Reproducibility: Manufactured using high-purity silica to provide consistent chromatographic performance and long operational life.
  • Versatile Laboratory Applications: Suitable for pharmaceutical quality control, research laboratories, environmental testing, food analysis, and chemical analysis.

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