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PROD,COL,PP,SCX10G,4X50MM

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PROD,COL,PP,SCX10G,4X50MM

The Thermo Scientific™ ProPac™ SCX-10 Guard Column (4 × 50 mm) is a high-performance strong cation exchange (SCX) HPLC guard column designed to protect analytical columns while delivering high-efficiency separation of proteins, peptides, and charged biomolecules. Packed with 10 µm nonporous polymeric particles featuring a sulfonate-based stationary phase, the column provides exceptional resolution, fast mass transfer, and excellent reproducibility for protein characterization and ion-exchange chromatography.

The ProPac™ SCX-10 Guard Column utilizes a thin hydrophilic surface layer that minimizes unwanted secondary interactions, ensuring accurate and reproducible separations. Its strong cation-exchange chemistry offers pH-based selectivity control, making it ideal for separating protein isoforms, monoclonal antibodies, charge variants, and other biomolecules that differ by only a single charged residue.

SKU: 79930 Category: Brand:

Specifications

Parameter Specification
Product Type Strong Cation Exchange (SCX) Guard Column
Brand Thermo Scientific™
Product Series ProPac™ SCX-10
Product Code PROD,COL,PP,SCX10G,4X50MM
Updated Catalog Number 079930
Column Dimensions 4 × 50 mm
Column Format Guard Column
Particle Size 10 µm
Particle Type Nonporous Polymeric Beads
Stationary Phase Sulfonate
Separation Mode Strong Cation Exchange (SCX)
pH Range 2–12
Maximum Pressure 3000 psi (207 bar)
Maximum Temperature 60°C
Primary Applications Protein & Peptide Separation, Charge Variant Analysis

Features

  • Strong cation exchange (SCX) HPLC guard column
  • Column dimensions: 4 × 50 mm
  • 10 µm nonporous polymeric particle technology
  • Sulfonate stationary phase
  • Thin hydrophilic surface layer minimizes secondary interactions
  • High-resolution protein and peptide separations
  • Fast mass transfer for improved chromatographic efficiency
  • Excellent pH-based selectivity control
  • Suitable for protein charge variant analysis
  • Designed to protect analytical HPLC columns
  • Broad operating pH range (2–12)
  • Maximum operating pressure of 3000 psi (207 bar)
  • High reproducibility and long service life
  • Compatible with ion-exchange chromatography workflows

Benefits

  • Protects Analytical Columns: Captures contaminants before they reach the analytical column, extending column life and reducing maintenance costs.
  • Exceptional Resolution: Nonporous polymeric particles provide sharp peaks and excellent separation of proteins and charge variants.
  • High-Efficiency Protein Separation: Ideal for separating monoclonal antibodies, protein isoforms, peptides, and biomolecules with minimal charge differences.
  • Reduced Secondary Interactions: Hydrophilic particle coating improves peak shape and chromatographic reproducibility.
  • Wide pH Compatibility: Operates across a pH range of 2–12, providing flexibility for various analytical methods.
  • Fast Mass Transfer: Delivers rapid and efficient separations with excellent chromatographic performance.
  • Reliable Performance: Strong cation exchange chemistry ensures consistent results in routine laboratory analysis.
  • Suitable for Biopharmaceutical Applications: Designed for protein characterization, quality control, and biotherapeutic development.

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